4-amino-3-trifluoromethyl-benzoic acid methyl ester

4-amino-3-trifluoromethyl-benzoic acid methyl ester - Names and Identifiers

Name	4-amino-3-trifluoromethyl-benzoic acid methyl ester
Synonyms	Methyl 4-amino-3-(trifluoromethyl) Methyl 4-Amino-3-trifluoromethylbenzoate Methyl 3-(trifluoroMethyl)-4-aMinobenzoate 4-amino-3-trifluoromethyl-benzoic acid methyl ester Benzoic acid, 4-amino-3-(trifluoromethyl)-, methyl ester benzoic acid, 4-amino-3-(trifluoromethyl)-, methyl ester
CAS	167760-75-0
InChI	InChI=1/C9H8F3NO2/c1-15-8(14)5-2-3-7(13)6(4-5)9(10,11)12/h2-4H,13H2,1H3

4-amino-3-trifluoromethyl-benzoic acid methyl ester - Physico-chemical Properties

Molecular Formula	C9H8F3NO2
Molar Mass	219.16
Density	1.343
Boling Point	305.7±42.0 °C(Predicted)
Flash Point	138.7°C
Vapor Presure	0.000808mmHg at 25°C
pKa	-0.67±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.491

4-amino-3-trifluoromethyl-benzoic acid methyl ester - Introduction

The methyl ester, also known as 3-trifluoromethylbenzoic acid 4-methyl ester, is an organic compound. Its molecular formula is C9H8F3NO2 and its molecular weight is 225.16g/mol.

The properties of the compound are as follows:
-Appearance: Colorless liquid or crystal.
-Melting point: 46-48 ° C
-Boiling point: 188-189 ° C
-Relative density (20 ° C):1.366
-refractive index (20 ° C):1.504-1.506

The main uses of the compound are as follows:
-Chemical synthesis: It is an important organic synthesis intermediate that can be used to synthesize drugs, pesticides, dyes and other organic compounds.
-Drug: It can be used as a synthetic intermediate for some drugs, such as anti-tuberculosis drugs and other active drugs.

Preparation method of acid methyl ester:
A commonly used preparation method is the reaction of methyl 3-trifluoromethylbenzoate with P-nitroaniline. Specific steps may be carried out under suitable reaction conditions, such as heating and addition of a catalyst.

When using acid methyl ester, you need to pay attention to its safety information:
-The compound is irritating and should avoid contact with skin and eyes.
-Wear appropriate personal protective equipment such as laboratory gloves, goggles and protective clothing during operation.
-Use with Good Laboratory and chemical handling practices.
-Waste shall be disposed of in accordance with relevant regulations.

Last Update：2024-04-09 19:05:47